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4MD6

Crystal structure of PDE5 in complex with inhibitor 5R

Summary for 4MD6
Entry DOI10.2210/pdb4md6/pdb
DescriptorcGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ... (6 entities in total)
Functional Keywordsprotein-inhibitor complex, phosphodiesterase, pde5 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight38347.73
Authors
Cui, W.,Huang, M.,Shao, Y.,Luo, H. (deposition date: 2013-08-22, release date: 2014-07-09)
Primary citationShang, N.N.,Shao, Y.X.,Cai, Y.H.,Guan, M.,Huang, M.,Cui, W.,He, L.,Yu, Y.J.,Huang, L.,Li, Z.,Bu, X.Z.,Ke, H.,Luo, H.B.
Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89:86-98, 2014
Cited by
PubMed: 24565909
DOI: 10.1016/j.bcp.2014.02.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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