4MD6
Crystal structure of PDE5 in complex with inhibitor 5R
Summary for 4MD6
Entry DOI | 10.2210/pdb4md6/pdb |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, phosphodiesterase, pde5 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38347.73 |
Authors | |
Primary citation | Shang, N.N.,Shao, Y.X.,Cai, Y.H.,Guan, M.,Huang, M.,Cui, W.,He, L.,Yu, Y.J.,Huang, L.,Li, Z.,Bu, X.Z.,Ke, H.,Luo, H.B. Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochem Pharmacol, 89:86-98, 2014 Cited by PubMed: 24565909DOI: 10.1016/j.bcp.2014.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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