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4MD6

Crystal structure of PDE5 in complex with inhibitor 5R

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 901
ChainResidue
AHIS613
AHIS617
AASP654
AASP764
A24E902
AZN903
AHOH1002

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 24E A 902
ChainResidue
AILE768
AGLN775
AVAL782
AALA783
APHE787
AILE813
AMET816
AGLN817
APHE820
ASO4901
ALEU725
AALA767

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN A 903
ChainResidue
AHIS617
AHIS653
AASP654
AASP764
ASO4901
AMG904
AHOH1001

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 904
ChainResidue
AASP654
AZN903
AHOH1001
AHOH1002
AHOH1003
AHOH1004
AHOH1005

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY
ChainResidueDetails
AHIS653-TYR664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AHIS617
AHIS653
AASP654
AASP764

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149
ChainResidueDetails
AGLN817

218853

PDB entries from 2024-04-24

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