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PDB: 196 件
4IC0
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Crystal Structure of PAI-1 in Complex with Gallate
分子名称: 3,4,5-trihydroxybenzoic acid, Plasminogen activator inhibitor 1
著者Hong, Z.B, Lin, Z.H, Gong, L.H, Huang, M.D.
登録日2012-12-09
公開日2013-12-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Crystal Structure of PAI-1 in Complex with Gallate
To be Published
4K23
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BU of 4k23 by Molmil
Structure of anti-uPAR Fab ATN-658
分子名称: anti-uPAR antibody, heavy chain, light chain
著者Yuan, C, Huang, M, Chen, L.
登録日2013-04-08
公開日2014-02-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Plos One, 9, 2014
4QGE
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BU of 4qge by Molmil
phosphodiesterase-9A in complex with inhibitor WYQ-C36D
分子名称: MAGNESIUM ION, N~2~-(1-cyclopentyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-N-(4-methoxyphenyl)-D-alaninamide, Phosphodiesterase 9A, ...
著者Shao, Y.-X, Huang, M, Cui, W, Ke, H.
登録日2014-05-22
公開日2014-12-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent.
J.Med.Chem., 57, 2014
3S8B
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BU of 3s8b by Molmil
Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP
分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D.
登録日2011-05-27
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
3S8C
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BU of 3s8c by Molmil
Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP
分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D.
登録日2011-05-27
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
5GVT
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BU of 5gvt by Molmil
Crystal structures of the serine protease domain of murine plasma kallikrein
分子名称: Plasma kallikrein, alpha-D-mannopyranose, beta-D-mannopyranose
著者Xu, M, Jiang, L, Huang, M.
登録日2016-09-06
公開日2017-11-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Crystal Structures of the Serine Protease Domain of Murine Plasma Kallikrein
Chin.J.Struct.Chem., 36, 2017
5F8T
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BU of 5f8t by Molmil
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
分子名称: CYS-PRO-LYS-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein light chain, SULFATE ION, ...
著者Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M.
登録日2015-12-09
公開日2016-12-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
To Be Published
5H7V
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Structure of full-length extracellular domain of HAI-1 at pH 4.6
分子名称: Kunitz-type protease inhibitor 1
著者Liu, M, Huang, M.
登録日2016-11-21
公開日2017-03-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.82 Å)
主引用文献The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
3OY6
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The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
分子名称: MH036, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
6A8O
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Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16
分子名称: Plasma kallikrein, alpha-D-mannopyranose, peptide inhibitor,, ...
著者Xu, M, Jiang, L, Huang, M.
登録日2018-07-09
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Febs Lett., 592, 2018
3OY5
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BU of 3oy5 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
分子名称: MH027, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OX7
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BU of 3ox7 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH4.6
分子名称: MH027, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-21
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
5XG4
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BU of 5xg4 by Molmil
Crystal structure of uPA in complex with quercetin
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Urokinase-type plasminogen activator
著者Jiang, L, Huang, M.
登録日2017-04-11
公開日2017-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A structural mechanism of flavonoids in inhibiting serine proteases
Food Funct, 8, 2017
3CX9
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Crystal Structure of Human serum albumin complexed with Myristic acid and lysophosphatidylethanolamine
分子名称: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, MYRISTIC ACID, Serum albumin
著者Guo, S, Yang, F, Chen, L, Bian, C, Huang, M.
登録日2008-04-24
公開日2009-04-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of transport of lysophospholipids by human serum albumin.
Biochem.J., 423, 2009
5E4K
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BU of 5e4k by Molmil
Structure of ligand binding region of uPARAP at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, C-type mannose receptor 2, ...
著者Yuan, C, Huang, M.
登録日2015-10-06
公開日2016-08-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Biochem.J., 473, 2016
3D69
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BU of 3d69 by Molmil
Crystal Structure of the Fab Fragment of an Anti-Factor IX Antibody 10C12
分子名称: anti-factor IX antibody, 10C12
著者Shi, X.L, Huang, M.D, Zeng, T.
登録日2008-05-19
公開日2009-03-31
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.77 Å)
主引用文献Crystal structure of Fab Fragment of an anti-Factor IX antibody 10C12
CHIN.J.STRUCT.CHEM., 27, 2008
5EW6
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BU of 5ew6 by Molmil
Structure of ligand binding region of uPARAP at pH 7.4 without calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type mannose receptor 2, ...
著者Yuan, C, Huang, M.
登録日2015-11-20
公開日2016-08-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding
Biochem.J., 473, 2016
3TBA
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BU of 3tba by Molmil
Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.
登録日2011-08-05
公開日2012-04-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
3TB9
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Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP
分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D.
登録日2011-08-05
公開日2012-04-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
2O8T
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Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors
分子名称: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, SULFATE ION, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8U
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Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
分子名称: BENZAMIDINE, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8W
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Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
分子名称: 1-phenylguanidine, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2NWN
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New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1
分子名称: Plasminogen activator, urokinase, upain-1
著者Zhao, G, Yuan, C, Wind, T, Andreasen, P.A, Huang, Z, Huang, M, Structural Genomics Consortium (SGC)
登録日2006-11-16
公開日2007-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
6KA4
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Cryo-EM structure of the AtMLKL3 tetramer
分子名称: F22L4.1 protein
著者Lisa, M, Huang, M, Zhang, X, Ryohei, T.N, Leila, B.K, Isabel, M.L.S, Florence, J, Viera, K, Dmitry, L, Jane, E.P, James, M.M, Kay, H, Paul, S.L, Chai, J, Takaki, M.
登録日2019-06-20
公開日2020-09-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of the AtMLKL3 tetramer
To Be Published
5WXT
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Crystal structure of uPA-S195A in complex with S2444
分子名称: (2R)-N-[2-[[(2S)-1-[[4-[bis(oxidanyl)amino]phenyl]amino]-5-carbamimidamido-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-5-oxidanylidene-pyrrolidine-2-carboxamide, Urokinase-type plasminogen activator chain B
著者Jiang, L, Huang, M.
登録日2017-01-08
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of uPA-S195A in complex with S2444
To Be Published

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