5AYR

The crystal structure of SAUGI/human UDG complex

Summary for 5AYR

• Entry DOI: 10.2210/pdb5ayr/pdb
• Related: 5AYS
• Descriptor: Uracil-DNA glycosylase, Uncharacterized protein, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: dna mimic protein, dna mimicking, uracil-dna glycosylase inhibitor, uracil-dna glycosylase, hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
• Total number of polymer chains: 4
• Total formula weight: 80062.05

Authors

Wang, H.C.,Ko, T.P.,Huang, M.F.,Wang, A.H.J. (deposition date: 2015-09-02, release date: 2016-06-08, Last modification date: 2023-11-08)

• Primary citation: Wang, H.C.,Ho, C.H.,Chou, C.C.,Ko, T.P.,Huang, M.F.,Hsu, K.C.,Wang, A.H.; Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase.; Nucleic Acids Res., 44:4440-4449, 2016; PubMed: 26980279; DOI: 10.1093/nar/gkw185

Experimental method

X-RAY DIFFRACTION (2.4 Å)