4DW2
The crystal structure of uPA in complex with the Fab fragment of mAb-112
Summary for 4DW2
Entry DOI | 10.2210/pdb4dw2/pdb |
Related | 4DVB |
Descriptor | Urokinase-type plasminogen activator, Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, ... (5 entities in total) |
Functional Keywords | urokinase-type plasminogen activator, antibody, serine protease, zymogen, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 3 |
Total formula weight | 74301.45 |
Authors | Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M. (deposition date: 2012-02-24, release date: 2013-01-16) |
Primary citation | Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M. Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J., 449:161-166, 2013 Cited by PubMed: 23016918DOI: 10.1042/BJ20121132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.97 Å) |
Structure validation
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