4DW2
The crystal structure of uPA in complex with the Fab fragment of mAb-112
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Urokinase-type plasminogen activator | polymer | 246 | 27715.6 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | Urokinase-type plasminogen activator chain B |
| 2 | B (H) | Fab fragment of pro-uPA antibody mAb-112 | polymer | 212 | 22889.8 | 1 | Mus musculus | ||
| 3 | C (L) | Fab fragment of pro-uPA antibody mAb-112 | polymer | 215 | 23600.0 | 1 | Mus musculus | ||
| 4 | D (L) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F, G (U, H, L) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
U: 16 - 243 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74205.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 74301.4 |
