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PDB: 175 件
6VI0
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Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 gp120, ...
著者Gorman, J, Kwong, P.D.
登録日2020-01-10
公開日2021-01-13
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.
Mabs, 13
6OT1
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BU of 6ot1 by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
分子名称: 0PV-b.01 heavy, 0PV-b.01 light, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2019-05-02
公開日2019-08-07
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
7UWF
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BU of 7uwf by Molmil
Human Rix1 sub-complex scaffold
分子名称: Modulator of non-genomic activity of estrogen receptor, WD repeat-containing protein 18
著者Gordon, J, Stanley, R.E.
登録日2022-05-03
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold.
Nat Commun, 13, 2022
7UR6
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BU of 7ur6 by Molmil
Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ...
著者Gorman, J, Kwong, P.D.
登録日2022-04-21
公開日2023-04-26
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664
To Be Published
6VTT
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BU of 6vtt by Molmil
Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者Gorman, J, Kwong, P.D.
登録日2020-02-13
公開日2020-04-08
最終更新日2021-10-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.
Cell Rep, 31, 2020
6VRW
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BU of 6vrw by Molmil
Cryo-EM structure of stabilized HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者Gorman, J, Kwong, P.D.
登録日2020-02-10
公開日2020-03-11
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.
Cell Rep, 31, 2020
9BF6
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BU of 9bf6 by Molmil
Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, Envelope glycoprotein gp41, ...
著者Gorman, J, Kwong, P.D.
登録日2024-04-16
公開日2024-07-31
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.
Cell Rep, 43, 2024
9BEW
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BU of 9bew by Molmil
Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs
分子名称: 10-1074 heavy chain, 10-1074 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2024-04-16
公開日2024-07-31
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.
Cell Rep, 43, 2024
9BER
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BU of 9ber by Molmil
Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者Gorman, J, Kwong, P.D.
登録日2024-04-16
公開日2024-07-31
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.
Cell Rep, 43, 2024
6WXL
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BU of 6wxl by Molmil
Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer
分子名称: 1D12 Light chain, 1D21 Heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Kwong, P.D.
登録日2020-05-11
公開日2021-06-09
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.
Structure, 2022
6XRT
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BU of 6xrt by Molmil
Cryo-EM structure of SHIV-elicited RHA1.V2.01 in complex with HIV-1 Env BG505 DS-SOSIP.664
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Gorman, J, Kwong, P.D.
登録日2020-07-13
公開日2020-10-07
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Science, 371, 2021
5DT1
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BU of 5dt1 by Molmil
Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody
分子名称: Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gorman, J, Kwong, P.D.
登録日2015-09-17
公開日2015-10-21
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.954 Å)
主引用文献New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.
J.Virol., 90, 2015
6VRY
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BU of 6vry by Molmil
Structure of NCI09 fab in complex with SIV V2 peptide
分子名称: NCI09 heavy chain, NCI09 light chain, SIV V2 peptide, ...
著者Gorman, J, Ahmadi, M, Kwong, P.D.
登録日2020-02-10
公開日2020-12-30
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献HIV vaccine candidate with V1 deletion reveals virus vulnerability to V2 antibodies
Iscience, 2020
6DE7
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BU of 6de7 by Molmil
Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 heavy chain, ...
著者Gorman, J, Kwong, P.D.
登録日2018-05-11
公開日2018-06-06
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (4.123 Å)
主引用文献Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
Cell Host Microbe, 23, 2018
5ESZ
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BU of 5esz by Molmil
Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244
分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH04 Heavy Chain, ...
著者Gorman, J, Yang, M, Kwong, P.D.
登録日2015-11-17
公開日2015-12-16
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (4.191 Å)
主引用文献Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.
Nat. Struct. Mol. Biol., 23, 2016
5ESV
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BU of 5esv by Molmil
Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256.
分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Yang, M, Kwong, P.D.
登録日2015-11-17
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.105 Å)
主引用文献Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.
Nat.Struct.Mol.Biol., 23, 2016
5EWI
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BU of 5ewi by Molmil
Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90
分子名称: VRC38.01 Heavy Chain, VRC38.01 Light Chain
著者Gorman, J, Kwong, P.D.
登録日2015-11-20
公開日2016-11-23
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.5996 Å)
主引用文献Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
Immunity, 46, 2017
3U4E
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BU of 3u4e by Molmil
Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG9 Heavy Chain, PG9 Light Chain, ...
著者Gorman, J, McLellan, J, Pancera, M, Kwong, P.D.
登録日2011-10-07
公開日2011-11-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.185 Å)
主引用文献Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
7L0L
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BU of 7l0l by Molmil
Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 316-310-1B11 Heavy Chain, 316-310-1B11 Light Chain, ...
著者Gorman, J, Kwong, P.D.
登録日2020-12-11
公開日2021-11-03
最終更新日2022-03-09
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
Nat Med, 28, 2022
7LQV
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BU of 7lqv by Molmil
Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-8 Heavy Chain, 4-8 Light chain, ...
著者Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
登録日2021-02-15
公開日2021-03-24
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite
Cell Host Microbe, 2021
7LQW
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BU of 7lqw by Molmil
Cryo-EM structure of NTD-directed neutralizing antibody 2-17 Fab in complex with SARS-CoV-2 S2P spike
分子名称: 2-17 Heavy Chain, 2-17 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
登録日2021-02-15
公開日2021-03-24
最終更新日2021-05-26
実験手法ELECTRON MICROSCOPY (4.47 Å)
主引用文献Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.
Cell Host Microbe, 29, 2021
7LPN
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BU of 7lpn by Molmil
Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Gorman, J, Kwong, P.D.
登録日2021-02-12
公開日2022-02-23
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Structure, 30, 2022
5VGJ
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BU of 5vgj by Molmil
Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90, bound to a scaffolded WITO V1V2 domain
分子名称: 1FD6-V1V2-WITO, 2-acetamido-2-deoxy-beta-D-glucopyranose, VRC38.01 Fab Heavy Chain, ...
著者Gorman, J, Li, J, Kwong, P.D.
登録日2017-04-11
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.456 Å)
主引用文献Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
Immunity, 46, 2017
7LZE
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BU of 7lze by Molmil
Cryo-EM Structure of disulfide stabilized HMPV F v4-B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
著者Gorman, J, Kwong, P.D.
登録日2021-03-09
公開日2021-08-25
最終更新日2021-10-06
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LY9
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BU of 7ly9 by Molmil
Cryo-EM structure of 2909 Fab in complex with 3BNC117 Fab and CAP256.wk34.c80 SOSIP.RnS2 N160K HIV-1 Env trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2909 Heavy Chain, ...
著者Gorman, J, Kwong, P.D.
登録日2021-03-06
公開日2021-08-18
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces.
Nat Commun, 12, 2021

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