6DE7

Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22

Summary for 6DE7

• Entry DOI: 10.2210/pdb6de7/pdb
• Descriptor: Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total)
• Functional Keywords: hiv-1, sosip, disulfide, trimer, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 180581.75

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2018-05-11, release date: 2018-06-06, Last modification date: 2023-10-11)

• Primary citation: Zhang, P.,Gorman, J.,Geng, H.,Liu, Q.,Lin, Y.,Tsybovsky, Y.,Go, E.P.,Dey, B.,Andine, T.,Kwon, A.,Patel, M.,Gururani, D.,Uddin, F.,Guzzo, C.,Cimbro, R.,Miao, H.,McKee, K.,Chuang, G.Y.,Martin, L.,Sironi, F.,Malnati, M.S.,Desaire, H.,Berger, E.A.,Mascola, J.R.,Dolan, M.A.,Kwong, P.D.,Lusso, P.; Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.; Cell Host Microbe, 23:832-844.e6, 2018; PubMed: 29902444; DOI: 10.1016/j.chom.2018.05.002

Experimental method

X-RAY DIFFRACTION (4.123 Å)