5DT1

Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody

Summary for 5DT1

• Entry DOI: 10.2210/pdb5dt1/pdb
• Related: 4OCR 4OCS 4OCW 4OD1 4OD3 4ODH 4ORG
• Descriptor: Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: vrc26, cap256, v1v2, hiv-1, env, envelope, broadly neutralizing, superinfection, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 51722.64

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2015-09-17, release date: 2015-10-21, Last modification date: 2023-11-15)

• Primary citation: Doria-Rose, N.A.,Bhiman, J.N.,Roark, R.S.,Schramm, C.A.,Gorman, J.,Chuang, G.Y.,Pancera, M.,Cale, E.M.,Ernandes, M.J.,Louder, M.K.,Asokan, M.,Bailer, R.T.,Druz, A.,Fraschilla, I.R.,Garrett, N.J.,Jarosinski, M.,Lynch, R.M.,McKee, K.,O'Dell, S.,Pegu, A.,Schmidt, S.D.,Staupe, R.P.,Sutton, M.S.,Wang, K.,Wibmer, C.K.,Haynes, B.F.,Abdool-Karim, S.,Shapiro, L.,Kwong, P.D.,Moore, P.L.,Morris, L.,Mascola, J.R.; New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.; J.Virol., 90:76-91, 2015; PubMed: 26468542; DOI: 10.1128/JVI.01791-15

Experimental method

X-RAY DIFFRACTION (1.954 Å)