6OT1

Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122

This is a non-PDB format compatible entry.

Summary for 6OT1

• Entry DOI: 10.2210/pdb6ot1/pdb
• Related: 6N16 6NF2 6OSY
• EMDB information: 20191
• Descriptor: Envelope glycoprotein gp41, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: fusion peptide, fp, hiv-1, sosip, vaccine, immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 24
• Total formula weight: 678861.51

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2019-05-02, release date: 2019-08-07, Last modification date: 2020-07-29)

• Primary citation: Kong, R.,Duan, H.,Sheng, Z.,Xu, K.,Acharya, P.,Chen, X.,Cheng, C.,Dingens, A.S.,Gorman, J.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Chuang, G.Y.,Chao, C.W.,Gu, Y.,Jafari, A.J.,Louder, M.K.,O'Dell, S.,Rowshan, A.P.,Viox, E.G.,Wang, Y.,Choi, C.W.,Corcoran, M.M.,Corrigan, A.R.,Dandey, V.P.,Eng, E.T.,Geng, H.,Foulds, K.E.,Guo, Y.,Kwon, Y.D.,Lin, B.,Liu, K.,Mason, R.D.,Nason, M.C.,Ohr, T.Y.,Ou, L.,Rawi, R.,Sarfo, E.K.,Schon, A.,Todd, J.P.,Wang, S.,Wei, H.,Wu, W.,Mullikin, J.C.,Bailer, R.T.,Doria-Rose, N.A.,Karlsson Hedestam, G.B.,Scorpio, D.G.,Overbaugh, J.,Bloom, J.D.,Carragher, B.,Potter, C.S.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.; Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.; Cell, 178:567-584.e19, 2019; PubMed: 31348886; DOI: 10.1016/j.cell.2019.06.030

Experimental method

ELECTRON MICROSCOPY (3.5 Å)