5EWI
Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90
Summary for 5EWI
Entry DOI | 10.2210/pdb5ewi/pdb |
Descriptor | VRC38.01 Heavy Chain, VRC38.01 Light Chain (3 entities in total) |
Functional Keywords | fab, hiv-1, v1v2, env, antibody, envelope, neutralizing, immune system |
Biological source | Homo sapiens More |
Cellular location | Secreted : P01834 |
Total number of polymer chains | 2 |
Total formula weight | 49275.12 |
Authors | Gorman, J.,Kwong, P.D. (deposition date: 2015-11-20, release date: 2016-11-23, Last modification date: 2023-09-27) |
Primary citation | Cale, E.M.,Gorman, J.,Radakovich, N.A.,Crooks, E.T.,Osawa, K.,Tong, T.,Li, J.,Nagarajan, R.,Ozorowski, G.,Ambrozak, D.R.,Asokan, M.,Bailer, R.T.,Bennici, A.K.,Chen, X.,Doria-Rose, N.A.,Druz, A.,Feng, Y.,Joyce, M.G.,Louder, M.K.,O'Dell, S.,Oliver, C.,Pancera, M.,Connors, M.,Hope, T.J.,Kepler, T.B.,Wyatt, R.T.,Ward, A.B.,Georgiev, I.S.,Kwong, P.D.,Mascola, J.R.,Binley, J.M. Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity, 46:777-791.e10, 2017 Cited by PubMed: 28514685DOI: 10.1016/j.immuni.2017.04.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5996 Å) |
Structure validation
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