5ESV

Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256.

Summary for 5ESV

• Entry DOI: 10.2210/pdb5esv/pdb
• Descriptor: CH03 Heavy Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, CH03 Light Chain, ... (11 entities in total)
• Functional Keywords: hiv-1, env, v1v2, ch0219, chavi, scaffold, cap256, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 9
• Total formula weight: 230235.51

Authors

Gorman, J.,Yang, M.,Kwong, P.D. (deposition date: 2015-11-17, release date: 2015-12-16, Last modification date: 2023-09-27)

• Primary citation: Gorman, J.,Soto, C.,Yang, M.M.,Davenport, T.M.,Guttman, M.,Bailer, R.T.,Chambers, M.,Chuang, G.Y.,DeKosky, B.J.,Doria-Rose, N.A.,Druz, A.,Ernandes, M.J.,Georgiev, I.S.,Jarosinski, M.C.,Joyce, M.G.,Lemmin, T.M.,Leung, S.,Louder, M.K.,McDaniel, J.R.,Narpala, S.,Pancera, M.,Stuckey, J.,Wu, X.,Yang, Y.,Zhang, B.,Zhou, T.,Program, N.C.,Mullikin, J.C.,Baxa, U.,Georgiou, G.,McDermott, A.B.,Bonsignori, M.,Haynes, B.F.,Moore, P.L.,Morris, L.,Lee, K.K.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.; Nat.Struct.Mol.Biol., 23:81-90, 2016; PubMed: 26689967; DOI: 10.1038/nsmb.3144

Experimental method

X-RAY DIFFRACTION (3.105 Å)