5ESV

Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
B	0016064	biological_process	immunoglobulin mediated immune response
B	0019814	cellular_component	immunoglobulin complex
B	0050853	biological_process	B cell receptor signaling pathway
B	0070062	cellular_component	extracellular exosome
B	0071735	cellular_component	IgG immunoglobulin complex
B	0071738	cellular_component	IgD immunoglobulin complex
B	0071742	cellular_component	IgE immunoglobulin complex
B	0071745	cellular_component	IgA immunoglobulin complex
B	0071753	cellular_component	IgM immunoglobulin complex
B	0072562	cellular_component	blood microparticle
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
D	0016064	biological_process	immunoglobulin mediated immune response
D	0019814	cellular_component	immunoglobulin complex
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0071738	cellular_component	IgD immunoglobulin complex
D	0071742	cellular_component	IgE immunoglobulin complex
D	0071745	cellular_component	IgA immunoglobulin complex
D	0071753	cellular_component	IgM immunoglobulin complex
D	0072562	cellular_component	blood microparticle
E	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E	0016114	biological_process	terpenoid biosynthetic process
E	0019031	cellular_component	viral envelope
F	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F	0016114	biological_process	terpenoid biosynthetic process
F	0019031	cellular_component	viral envelope
G	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G	0016114	biological_process	terpenoid biosynthetic process
G	0019031	cellular_component	viral envelope
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016020	cellular_component	membrane
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
B	TYR192-HIS198
A	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00107

Chain	Residue	Details
E	ASP120
F	HIS122
F	HIS207
F	ASP221
F	PHE226
F	GLY303
F	GLY310
F	CYS313
G	ASP120
G	HIS122
G	HIS207
E	HIS122
G	ASP221
G	PHE232
G	GLY303
G	GLY310
G	CYS313
E	HIS207
E	ASP221
E	PHE232
E	GLY303
E	GLY310
E	CYS313
F	ASP120

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00107

Chain	Residue	Details
E	PHE304
F	PHE304
G	PHE304

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