5VGJ

Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90, bound to a scaffolded WITO V1V2 domain

Summary for 5VGJ

• Entry DOI: 10.2210/pdb5vgj/pdb
• Related: 5EWI
• Descriptor: 1FD6-V1V2-WITO, VRC38.01 Fab Heavy Chain, VRC38.01 Fab Light Chain, ... (6 entities in total)
• Functional Keywords: fab, hiv-1, v1v2, env, antibody, envelope, neutralizing, immune system, wito, 1fd6, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 67638.83

Authors

Gorman, J.,Li, J.,Kwong, P.D. (deposition date: 2017-04-11, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Cale, E.M.,Gorman, J.,Radakovich, N.A.,Crooks, E.T.,Osawa, K.,Tong, T.,Li, J.,Nagarajan, R.,Ozorowski, G.,Ambrozak, D.R.,Asokan, M.,Bailer, R.T.,Bennici, A.K.,Chen, X.,Doria-Rose, N.A.,Druz, A.,Feng, Y.,Joyce, M.G.,Louder, M.K.,O'Dell, S.,Oliver, C.,Pancera, M.,Connors, M.,Hope, T.J.,Kepler, T.B.,Wyatt, R.T.,Ward, A.B.,Georgiev, I.S.,Kwong, P.D.,Mascola, J.R.,Binley, J.M.; Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.; Immunity, 46:777-791.e10, 2017; PubMed: 28514685; DOI: 10.1016/j.immuni.2017.04.011

Experimental method

X-RAY DIFFRACTION (3.456 Å)