6VTT

Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2

Summary for 6VTT

• Entry DOI: 10.2210/pdb6vtt/pdb
• Related: 5DT1 6VRW
• EMDB information: 21372 21383
• Descriptor: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: v1v2, vrc26, cap256, hiv-1, sosip, vaccine, superinfecting, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 284495.39

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2020-02-13, release date: 2020-04-08, Last modification date: 2021-10-06)

• Primary citation: Gorman, J.,Chuang, G.Y.,Lai, Y.T.,Shen, C.H.,Boyington, J.C.,Druz, A.,Geng, H.,Louder, M.K.,McKee, K.,Rawi, R.,Verardi, R.,Yang, Y.,Zhang, B.,Doria-Rose, N.A.,Lin, B.,Moore, P.L.,Morris, L.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.; Cell Rep, 31:107488-107488, 2020; PubMed: 32268107; DOI: 10.1016/j.celrep.2020.03.052

Experimental method

ELECTRON MICROSCOPY (3.7 Å)