6VTT

Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	F, E, G	Envelope glycoprotein gp120	polymer	471	53322.4	3	Pfam (PF00516) UniProt (by SIFTS) (A0A0N9FF17) In PDB	Human immunodeficiency virus 1 (HIV-1)
2	H	VRC26.25 Heavy Chain	polymer	257	28083.5	1		Homo sapiens (Human)
3	L	VRC26.25 Light Chain	polymer	217	23052.6	1	UniProt (A2NUT2) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	A, B, C	Envelope glycoprotein gp41	polymer	154	17355.7	3		Human immunodeficiency virus 1 (HIV-1)
5	a, c, d, D, I...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
6	K, X	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
7	O, W	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
8	T	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
9	V	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
10	b	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G56014GC)
11	E, G, F, A, B...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	41	Chemie (NAG)

Sequence modifications

L: 1 - 115 (PDB: 6VTT)
L: 116 - 213 (UniProt: A2NUT2)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	263170.5
Branched	Number of molecules	22
	Total formula weight	12255.4
Non-Polymers*	Number of molecules	41
	Total formula weight	9069.5
All*	Total formula weight	284495.4

*Water molecules are not included.