5DT1
Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody
Summary for 5DT1
Entry DOI | 10.2210/pdb5dt1/pdb |
Related | 4OCR 4OCS 4OCW 4OD1 4OD3 4ODH 4ORG |
Descriptor | Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | vrc26, cap256, v1v2, hiv-1, env, envelope, broadly neutralizing, superinfection, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 51722.64 |
Authors | Gorman, J.,Kwong, P.D. (deposition date: 2015-09-17, release date: 2015-10-21, Last modification date: 2023-11-15) |
Primary citation | Doria-Rose, N.A.,Bhiman, J.N.,Roark, R.S.,Schramm, C.A.,Gorman, J.,Chuang, G.Y.,Pancera, M.,Cale, E.M.,Ernandes, M.J.,Louder, M.K.,Asokan, M.,Bailer, R.T.,Druz, A.,Fraschilla, I.R.,Garrett, N.J.,Jarosinski, M.,Lynch, R.M.,McKee, K.,O'Dell, S.,Pegu, A.,Schmidt, S.D.,Staupe, R.P.,Sutton, M.S.,Wang, K.,Wibmer, C.K.,Haynes, B.F.,Abdool-Karim, S.,Shapiro, L.,Kwong, P.D.,Moore, P.L.,Morris, L.,Mascola, J.R. New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency. J.Virol., 90:76-91, 2015 Cited by PubMed: 26468542DOI: 10.1128/JVI.01791-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.954 Å) |
Structure validation
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