7L0L

Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer

Summary for 7L0L

Entry DOI	10.2210/pdb7l0l/pdb
EMDB information	23098
Descriptor	316-310-1B11 Light Chain, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... (5 entities in total)
Functional Keywords	vrc, immune system, vrc316, h2, fab, flu, immune system-viral protein complex, immune system/viral protein
Biological source	Homo sapiens More
Total number of polymer chains	12
Total formula weight	341768.00
Authors	Gorman, J.,Kwong, P.D. (deposition date: 2020-12-11, release date: 2021-11-03, Last modification date: 2022-03-09)
Primary citation	Andrews, S.F.,Raab, J.E.,Gorman, J.,Gillespie, R.A.,Cheung, C.S.F.,Rawi, R.,Cominsky, L.Y.,Boyington, J.C.,Creanga, A.,Shen, C.H.,Harris, D.R.,Olia, A.S.,Nazzari, A.F.,Zhou, T.,Houser, K.V.,Chen, G.L.,Mascola, J.R.,Graham, B.S.,Kanekiyo, M.,Ledgerwood, J.E.,Kwong, P.D.,McDermott, A.B. A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination. Nat Med, 28:373-382, 2022 Cited by PubMed: 35115707 DOI: 10.1038/s41591-021-01636-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.85 Å)

Structure validation