7L0L
Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (L, J, K) | 316-310-1B11 Light Chain | polymer | 215 | 23460.0 | 3 | Homo sapiens | ||
| 2 | B, F, J (A, C, D) | Hemagglutinin HA1 chain | polymer | 345 | 38802.2 | 3 | UniProt (Q4ZH98) | Influenza A virus (A/Canada/720/2005(H2N2)) | |
| 3 | C, G, K (B, E, F) | Hemagglutinin HA2 chain | polymer | 222 | 25489.4 | 3 | UniProt (Q4ZH98) | Influenza A virus (A/Canada/720/2005(H2N2)) | |
| 4 | D, H, L (H, G, I) | 316-310-1B11 Heavy Chain | polymer | 236 | 25065.1 | 3 | Homo sapiens | ||
| 5 | AA, M, N, O, P... (F, A, B, C, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) |
Sequence modifications
A, C, D: -4 - 329 (UniProt: Q4ZH98)
B, E, F: 1 - 177 (UniProt: Q4ZH98)
| PDB | External Database | Details |
|---|---|---|
| Cys 30 | Leu 35 | conflict |
| Arg 330 | - | expression tag |
| Arg 331 | - | expression tag |
| Arg 332 | - | expression tag |
| Arg 333 | - | expression tag |
| Arg 334 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | Gly 387 | conflict |
| Gly 178 | - | expression tag |
| Arg 179 | - | expression tag |
| Leu 180 | - | expression tag |
| Val 181 | - | expression tag |
| Pro 182 | - | expression tag |
| Arg 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Ser 185 | - | expression tag |
| Pro 186 | - | expression tag |
| Gly 187 | - | expression tag |
| Ser 188 | - | expression tag |
| Gly 189 | - | expression tag |
| Tyr 190 | - | expression tag |
| Ile 191 | - | expression tag |
| Pro 192 | - | expression tag |
| Glu 193 | - | expression tag |
| Ala 194 | - | expression tag |
| Pro 195 | - | expression tag |
| Arg 196 | - | expression tag |
| Asp 197 | - | expression tag |
| Gly 198 | - | expression tag |
| Gln 199 | - | expression tag |
| Ala 200 | - | expression tag |
| Tyr 201 | - | expression tag |
| Val 202 | - | expression tag |
| Arg 203 | - | expression tag |
| Lys 204 | - | expression tag |
| Asp 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Glu 207 | - | expression tag |
| Trp 208 | - | expression tag |
| Val 209 | - | expression tag |
| Leu 210 | - | expression tag |
| Leu 211 | - | expression tag |
| Ser 212 | - | expression tag |
| Thr 213 | - | expression tag |
| Phe 214 | - | expression tag |
| Leu 215 | - | expression tag |
| Gly 216 | - | expression tag |
| His 217 | - | expression tag |
| His 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 338449.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3318.1 | |
| All* | Total formula weight | 341768.0 |
