6VI0

Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP

Summary for 6VI0

• Entry DOI: 10.2210/pdb6vi0/pdb
• EMDB information: 21208
• Descriptor: Envelope glycoprotein gp41, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: cd4, hiv-1, sosip, vaccine, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 383728.40

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2020-01-10, release date: 2021-01-13, Last modification date: 2021-08-25)

• Primary citation: Kwon, Y.D.,Asokan, M.,Gorman, J.,Zhang, B.,Liu, Q.,Louder, M.K.,Lin, B.C.,McKee, K.,Pegu, A.,Verardi, R.,Yang, E.S.,Program, V.P.,Carlton, K.,Doria-Rose, N.A.,Lusso, P.,Mascola, J.R.,Kwong, P.D.; A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.; Mabs, 13:1946918-1946918, ; PubMed: 34328065; DOI: 10.1080/19420862.2021.1946918

Experimental method

ELECTRON MICROSCOPY (3.43 Å)