4CI2
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![BU of 4ci2 by Molmil](/molmil-images/mine/4ci2) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI1
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![BU of 4ci1 by Molmil](/molmil-images/mine/4ci1) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI3
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![BU of 4ci3 by Molmil](/molmil-images/mine/4ci3) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4A0K
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![BU of 4a0k by Molmil](/molmil-images/mine/4a0k) | STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX | 分子名称: | 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ... | 著者 | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | 登録日 | 2011-09-09 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (5.93 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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4A0L
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![BU of 4a0l by Molmil](/molmil-images/mine/4a0l) | Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex | 分子名称: | 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ... | 著者 | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | 登録日 | 2011-09-09 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (7.4 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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7B1H
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![BU of 7b1h by Molmil](/molmil-images/mine/7b1h) | |
7B1F
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![BU of 7b1f by Molmil](/molmil-images/mine/7b1f) | |
7B1J
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6XMX
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![BU of 6xmx by Molmil](/molmil-images/mine/6xmx) | Cryo-EM structure of BCL6 bound to BI-3802 | 分子名称: | 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide, B-cell lymphoma 6 protein | 著者 | Yoon, H, Burman, S.S.R, Hunkeler, M, Nowak, R.P, Fischer, E.S. | 登録日 | 2020-07-01 | 公開日 | 2020-11-25 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Small-molecule-induced polymerization triggers degradation of BCL6. Nature, 588, 2020
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8G46
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![BU of 8g46 by Molmil](/molmil-images/mine/8g46) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2 | 分子名称: | Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DET1- and DDB1-associated protein 1, ... | 著者 | Ma, M.W, Hunkeler, M, Jin, C.Y, Fischer, E.S. | 登録日 | 2023-02-08 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Biorxiv, 2023
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8UWB
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![BU of 8uwb by Molmil](/molmil-images/mine/8uwb) | Crystal structure of PP2A PPP2R1A-PPP2CA-PPP2R5E phosphatase. | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | 著者 | Wachter, F, Nowak, R.P, Fischer, E.S. | 登録日 | 2023-11-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes. J.Biol.Chem., 300, 2024
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8TNR
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![BU of 8tnr by Molmil](/molmil-images/mine/8tnr) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNP
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![BU of 8tnp by Molmil](/molmil-images/mine/8tnp) | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNQ
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![BU of 8tnq by Molmil](/molmil-images/mine/8tnq) | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TL6
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![BU of 8tl6 by Molmil](/molmil-images/mine/8tl6) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF5 | 分子名称: | DDB1- and CUL4-associated factor 5, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1 | 著者 | Yue, H, Hunkeler, M, Roy Burman, S.S, Fischer, E.S. | 登録日 | 2023-07-26 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature, 628, 2024
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3GJF
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![BU of 3gjf by Molmil](/molmil-images/mine/3gjf) | Rational development of high-affinity T-cell receptor-like antibodies | 分子名称: | Antibody heavy chain, Antibody light chain, Beta-2-microglobulin, ... | 著者 | Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E, Kleber, S, Stenner-Liewen, F, Bauer, S, McMichael, A, Knuth, A, Abken, H, Hombach, A.A, Cerundolo, V, Jones, E.Y, Renner, C. | 登録日 | 2009-03-08 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rational development of high-affinity T-cell receptor-like antibodies Proc.Natl.Acad.Sci.USA, 106, 2009
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3GJE
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![BU of 3gje by Molmil](/molmil-images/mine/3gje) | Rational development of high-affinity T-cell receptor-like antibodies | 分子名称: | Fab Heavy Chain, Fab Light Chain | 著者 | Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E, Kleber, S, Stenner-Liewen, F, Bauer, S, McMichael, A, Knuth, A, Abken, H, Hombach, A.A, Cerundolo, V, Jones, E.Y, Renner, C. | 登録日 | 2009-03-08 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Rational development of high-affinity T-cell receptor-like antibodies Proc.Natl.Acad.Sci.USA, 106, 2009
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3HAE
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![BU of 3hae by Molmil](/molmil-images/mine/3hae) | Rational development of high-affinity T-cell receptor-like antibodies | 分子名称: | Antibody heavy chain, Antibody light chain, Beta-2-microglobulin, ... | 著者 | Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E. | 登録日 | 2009-05-01 | 公開日 | 2009-05-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Rational development of high-affinity T-cell receptor-like antibodies Proc.Natl.Acad.Sci.USA, 106, 2009
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7U20
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![BU of 7u20 by Molmil](/molmil-images/mine/7u20) | Crystal structure of human METTL1 and WDR4 complex | 分子名称: | SULFATE ION, tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | 著者 | Li, J, Nowak, R.P, Fischer, E.S, Gregory, R. | 登録日 | 2022-02-22 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature, 613, 2023
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8E2D
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8E2G
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![BU of 8e2g by Molmil](/molmil-images/mine/8e2g) | |
8E2J
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8E2E
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![BU of 8e2e by Molmil](/molmil-images/mine/8e2e) | |
8E2I
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![BU of 8e2i by Molmil](/molmil-images/mine/8e2i) | Cryo-EM structure of BIRC6/Smac | 分子名称: | Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein | 著者 | Hunkeler, M, Fischer, E.S. | 登録日 | 2022-08-15 | 公開日 | 2023-02-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379, 2023
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8E2F
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