8TNP
Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40
Summary for 8TNP
Entry DOI | 10.2210/pdb8tnp/pdb |
EMDB information | 41423 41424 41425 |
Descriptor | Protein cereblon, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... (5 entities in total) |
Functional Keywords | ubiquitin, crbn, directed evolution, zinc finger, imid, molecular glue, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 202048.61 |
Authors | Roy Burman, S.S.,Hunkeler, M.,Fischer, E.S. (deposition date: 2023-08-02, release date: 2024-03-13, Last modification date: 2024-04-03) |
Primary citation | Mercer, J.A.M.,DeCarlo, S.J.,Roy Burman, S.S.,Sreekanth, V.,Nelson, A.T.,Hunkeler, M.,Chen, P.J.,Donovan, K.A.,Kokkonda, P.,Tiwari, P.K.,Shoba, V.M.,Deb, A.,Choudhary, A.,Fischer, E.S.,Liu, D.R. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383:eadk4422-eadk4422, 2024 Cited by PubMed: 38484051DOI: 10.1126/science.adk4422 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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