8TNP
Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005634 | cellular_component | nucleus |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| B | 0031333 | biological_process | negative regulation of protein-containing complex assembly |
| B | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| B | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| B | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
| B | 0035641 | biological_process | locomotory exploration behavior |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0044325 | molecular_function | transmembrane transporter binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0060173 | biological_process | limb development |
| C | 0005515 | molecular_function | protein binding |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008643 | biological_process | carbohydrate transport |
| C | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| C | 0015768 | biological_process | maltose transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0034219 | biological_process | carbohydrate transmembrane transport |
| C | 0034289 | biological_process | detection of maltose stimulus |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0042956 | biological_process | maltodextrin transmembrane transport |
| C | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| C | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0060326 | biological_process | cell chemotaxis |
| C | 1901982 | molecular_function | maltose binding |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpi..CgftCrqkgnllrHinl..H |
| Chain | Residue | Details |
| C | CYS19-HIS39 |
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| C | PRO-270-ASN-253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 343 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Region: {"description":"Required for both high-affinity DNA binding and pericentromeric heterochromatin localization","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for both pericentromeric heterochromatin localization and complete DNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q03267","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
