8TNQ

Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1

Summary for 8TNQ

• Entry DOI: 10.2210/pdb8tnq/pdb
• EMDB information: 41423 41424 41425
• Descriptor: DNA damage-binding protein 1, Protein cereblon, Maltose/maltodextrin-binding periplasmic protein,SD40, ... (5 entities in total)
• Functional Keywords: ubiquitin, crbn, directed evolution, zinc finger, imid, molecular glue, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 202118.70

Authors

Roy Burman, S.S.,Hunkeler, M.,Fischer, E.S. (deposition date: 2023-08-02, release date: 2024-03-13, Last modification date: 2024-04-03)

• Primary citation: Mercer, J.A.M.,DeCarlo, S.J.,Roy Burman, S.S.,Sreekanth, V.,Nelson, A.T.,Hunkeler, M.,Chen, P.J.,Donovan, K.A.,Kokkonda, P.,Tiwari, P.K.,Shoba, V.M.,Deb, A.,Choudhary, A.,Fischer, E.S.,Liu, D.R.; Continuous evolution of compact protein degradation tags regulated by selective molecular glues.; Science, 383:eadk4422-eadk4422, 2024; PubMed: 38484051; DOI: 10.1126/science.adk4422

Experimental method

ELECTRON MICROSCOPY (2.41 Å)