8G46

Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2

Summary for 8G46

• Entry DOI: 10.2210/pdb8g46/pdb
• EMDB information: 29714
• Descriptor: DNA damage-binding protein 1, DDB1- and CUL4-associated factor 16, Bromodomain-containing protein 4, ... (7 entities in total)
• Functional Keywords: e3 ligase, ubiquitin, degrader, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 148651.12

Authors

Ma, M.W.,Hunkeler, M.,Jin, C.Y.,Fischer, E.S. (deposition date: 2023-02-08, release date: 2023-03-08)

• Primary citation: Li, Y.D.,Ma, M.W.,Hassan, M.M.,Hunkeler, M.,Teng, M.,Puvar, K.,Lumpkin, R.,Sandoval, B.,Jin, C.Y.,Ficarro, S.B.,Wang, M.Y.,Xu, S.,Groendyke, B.J.,Sigua, L.H.,Tavares, I.,Zou, C.,Tsai, J.M.,Park, P.M.C.,Yoon, H.,Majewski, F.C.,Marto, J.A.,Qi, J.,Nowak, R.P.,Donovan, K.A.,Slabicki, M.,Gray, N.S.,Fischer, E.S.,Ebert, B.L.; Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.; Biorxiv, 2023; PubMed: 36824856; DOI: 10.1101/2023.02.14.528208

Experimental method

ELECTRON MICROSCOPY (2.2 Å)