Rational development of high-affinity T-cell receptor-like antibodies

Summary for 3GJF

Related3GJE 3GJG
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NYESO-1 peptide, ... (6 entities in total)
Functional Keywordsmhc, antibody, disulfide bond, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, polymorphism, transmembrane, ubl conjugation, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, immune system
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted P61769
Total number of polymer chains10
Total molecular weight181421.65
Primary citation
Stewart-Jones, G.,Wadle, A.,Hombach, A.,Shenderov, E.,Held, G.,Fischer, E.,Kleber, S.,Stenner-Liewen, F.,Bauer, S.,McMichael, A.,Knuth, A.,Abken, H.,Hombach, A.A.,Cerundolo, V.,Jones, E.Y.,Renner, C.
Rational development of high-affinity T-cell receptor-like antibodies
Proc.Natl.Acad.Sci.USA, 106:5784-5788, 2009
PubMed: 19307587 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0901425106
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247111.1%5.8%7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution