8TL6

Cryo-EM structure of DDB1deltaB-DDA1-DCAF5

Summary for 8TL6

• Entry DOI: 10.2210/pdb8tl6/pdb
• EMDB information: 41363
• Descriptor: DNA damage-binding protein 1, DDB1- and CUL4-associated factor 5, DET1- and DDB1-associated protein 1 (3 entities in total)
• Functional Keywords: e3 ligase, protein degradation, cryo-em, wd40, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 219916.43

Authors

Yue, H.,Hunkeler, M.,Roy Burman, S.S.,Fischer, E.S. (deposition date: 2023-07-26, release date: 2024-04-03, Last modification date: 2024-04-17)

• Primary citation: Radko-Juettner, S.,Yue, H.,Myers, J.A.,Carter, R.D.,Robertson, A.N.,Mittal, P.,Zhu, Z.,Hansen, B.S.,Donovan, K.A.,Hunkeler, M.,Rosikiewicz, W.,Wu, Z.,McReynolds, M.G.,Roy Burman, S.S.,Schmoker, A.M.,Mageed, N.,Brown, S.A.,Mobley, R.J.,Partridge, J.F.,Stewart, E.A.,Pruett-Miller, S.M.,Nabet, B.,Peng, J.,Gray, N.S.,Fischer, E.S.,Roberts, C.W.M.; Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.; Nature, 628:442-449, 2024; PubMed: 38538798; DOI: 10.1038/s41586-024-07250-1

Experimental method

ELECTRON MICROSCOPY (2.63 Å)