8E2I

Cryo-EM structure of BIRC6/Smac

This is a non-PDB format compatible entry.

Summary for 8E2I

• Entry DOI: 10.2210/pdb8e2i/pdb
• EMDB information: 27832 27833 27834 27835 27836 27837 27838 27839 27840 27841
• Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein (3 entities in total)
• Functional Keywords: ubiquitin, e3 ligase, apoptosis, autophagy, iap, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 1122377.84

Authors

Hunkeler, M.,Fischer, E.S. (deposition date: 2022-08-15, release date: 2023-02-15, Last modification date: 2023-03-29)

• Primary citation: Hunkeler, M.,Jin, C.Y.,Fischer, E.S.; Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.; Science, 379:1105-1111, 2023; PubMed: 36758104; DOI: 10.1126/science.ade5750

Experimental method

ELECTRON MICROSCOPY (3.04 Å)