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8E2I

Cryo-EM structure of BIRC6/Smac

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000922cellular_componentspindle pole
A0001890biological_processplacenta development
A0004842molecular_functionubiquitin-protein transferase activity
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0005813cellular_componentcentrosome
A0005815cellular_componentmicrotubule organizing center
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0030496cellular_componentmidbody
A0032465biological_processregulation of cytokinesis
A0042127biological_processregulation of cell population proliferation
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0051301biological_processcell division
A0060711biological_processlabyrinthine layer development
A0060712biological_processspongiotrophoblast layer development
A0061631molecular_functionubiquitin conjugating enzyme activity
A0090543cellular_componentFlemming body
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000922cellular_componentspindle pole
B0001890biological_processplacenta development
B0004842molecular_functionubiquitin-protein transferase activity
B0004869molecular_functioncysteine-type endopeptidase inhibitor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0005813cellular_componentcentrosome
B0005815cellular_componentmicrotubule organizing center
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0030496cellular_componentmidbody
B0032465biological_processregulation of cytokinesis
B0042127biological_processregulation of cell population proliferation
B0042981biological_processregulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0051301biological_processcell division
B0060711biological_processlabyrinthine layer development
B0060712biological_processspongiotrophoblast layer development
B0061631molecular_functionubiquitin conjugating enzyme activity
B0090543cellular_componentFlemming body
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
E0005739cellular_componentmitochondrion
E0006915biological_processapoptotic process
E0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
F0005739cellular_componentmitochondrion
F0006915biological_processapoptotic process
F0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388
ChainResidueDetails
ACYS4666
BCYS4666

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88738
ChainResidueDetails
ASER473
ASER482
BSER473
BSER482

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER480
BSER480

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER581
ASER590
ASER2222
ASER2955
ASER4023
BSER581
BSER590
BSER2222
BSER2955
BSER4023

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR1710
BTHR1710

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR3931
BTHR3931

219869

PDB entries from 2024-05-15

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