8E2J
Cryo-EM structure of BIRC6/Smac (from local refinement 1)
Summary for 8E2J
| Entry DOI | 10.2210/pdb8e2j/pdb |
| EMDB information | 27832 27833 27834 27835 27836 27837 27838 27839 27840 27841 |
| Descriptor | Diablo IAP-binding mitochondrial protein, Baculoviral IAP repeat-containing protein 6 (2 entities in total) |
| Functional Keywords | ubiquitin, e3 ligase, apoptosis, autophagy, iap, ligase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 54061.22 |
| Authors | Hunkeler, M.,Fischer, E.S. (deposition date: 2022-08-15, release date: 2023-02-15, Last modification date: 2023-03-29) |
| Primary citation | Hunkeler, M.,Jin, C.Y.,Fischer, E.S. Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science, 379:1105-1111, 2023 Cited by PubMed: 36758104DOI: 10.1126/science.ade5750 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.44 Å) |
Structure validation
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