6XMX

Cryo-EM structure of BCL6 bound to BI-3802

Summary for 6XMX

Entry DOI	10.2210/pdb6xmx/pdb
EMDB information	22265
Descriptor	B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide (2 entities in total)
Functional Keywords	transcription factor, degrader, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	359922.26
Authors	Yoon, H.,Burman, S.S.R.,Hunkeler, M.,Nowak, R.P.,Fischer, E.S. (deposition date: 2020-07-01, release date: 2020-11-25, Last modification date: 2024-03-06)
Primary citation	Slabicki, M.,Yoon, H.,Koeppel, J.,Nitsch, L.,Roy Burman, S.S.,Di Genua, C.,Donovan, K.A.,Sperling, A.S.,Hunkeler, M.,Tsai, J.M.,Sharma, R.,Guirguis, A.,Zou, C.,Chudasama, P.,Gasser, J.A.,Miller, P.G.,Scholl, C.,Frohling, S.,Nowak, R.P.,Fischer, E.S.,Ebert, B.L. Small-molecule-induced polymerization triggers degradation of BCL6. Nature, 588:164-168, 2020 Cited by PubMed: 33208943 DOI: 10.1038/s41586-020-2925-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation