6XMX
Cryo-EM structure of BCL6 bound to BI-3802
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | B-cell lymphoma 6 protein | polymer | 400 | 44505.3 | 8 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | I, J, K, L, M... (A, B, C, D, E...) | 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide | non-polymer | 485.0 | 8 | Chemie (U52) |
Sequence modifications
A, B, C, D, E, F, G, H: 5 - 360 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Met -39 | - | initiating methionine |
| Asp -38 | - | expression tag |
| Trp -37 | - | expression tag |
| Ser -36 | - | expression tag |
| His -35 | - | expression tag |
| Pro -34 | - | expression tag |
| Gln -33 | - | expression tag |
| Phe -32 | - | expression tag |
| Glu -31 | - | expression tag |
| Lys -30 | - | expression tag |
| Ser -29 | - | expression tag |
| Ala -28 | - | expression tag |
| Val -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Leu -25 | - | expression tag |
| Asn -24 | - | expression tag |
| Asp -23 | - | expression tag |
| Ile -22 | - | expression tag |
| Phe -21 | - | expression tag |
| Glu -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Gln -18 | - | expression tag |
| Lys -17 | - | expression tag |
| Ile -16 | - | expression tag |
| Glu -15 | - | expression tag |
| Trp -14 | - | expression tag |
| His -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Cys 160 | Arg 160 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 356042.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3879.8 | |
| All* | Total formula weight | 359922.3 |
