3I7C
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2IH2
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4XRS
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![BU of 4xrs by Molmil](/molmil-images/mine/4xrs) | Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA | 分子名称: | DNA (5'-D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3'), ... | 著者 | Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Morgunova, E, Taipale, J. | 登録日 | 2015-01-21 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature, 527, 2015
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1JWL
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![BU of 1jwl by Molmil](/molmil-images/mine/1jwl) | Structure of the Dimeric lac Repressor/Operator O1/ONPF Complex | 分子名称: | 2-nitrophenyl beta-D-fucopyranoside, 5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', ... | 著者 | Bell, C.E, Lewis, M. | 登録日 | 2001-09-04 | 公開日 | 2001-10-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Crystallographic analysis of Lac repressor bound to natural operator O1. J.Mol.Biol., 312, 2001
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6MKF
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![BU of 6mkf by Molmil](/molmil-images/mine/6mkf) | Crystal structure of penicillin binding protein 5 (PBP5) from Enterococcus faecium in the imipenem-bound form | 分子名称: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, SULFATE ION, penicillin binding protein 5 (PBP5) | 著者 | Moon, T.M, Lee, C, D'Andrea, E.D, Peti, W, Page, R. | 登録日 | 2018-09-25 | 公開日 | 2018-10-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
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7Q89
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![BU of 7q89 by Molmil](/molmil-images/mine/7q89) | OleP mutant G92W in complex with 6DEB | 分子名称: | 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ... | 著者 | Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E. | 登録日 | 2021-11-10 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics. Biomolecules, 12, 2021
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8BZL
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![BU of 8bzl by Molmil](/molmil-images/mine/8bzl) | Human 20S Proteasome in complex with peptide activator peptide BLM42 | 分子名称: | ARG-SER-TYR-TYR-SER, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Henneberg, F, Chari, A, Jankowska, E, Witkowska, J. | 登録日 | 2022-12-15 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Peptidic, Blm10-based activators of human 20S proteasome in vitro and in cellulo enhance degradation of proteins connected with neurodegeneration. To Be Published
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7Q6X
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![BU of 7q6x by Molmil](/molmil-images/mine/7q6x) | OleP mutant S240Y in complex with 6DEB | 分子名称: | 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ... | 著者 | Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E. | 登録日 | 2021-11-09 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics. Biomolecules, 12, 2021
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4XX8
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4XYB
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![BU of 4xyb by Molmil](/molmil-images/mine/4xyb) | GRANULICELLA M. FORMATE DEHYDROGENASE (FDH) IN COMPLEX WITH NADP(+) AND NaN3 | 分子名称: | 1,2-ETHANEDIOL, AZIDE ION, Formate dehydrogenase, ... | 著者 | Cendron, L, Fogal, S, Beneventi, E, Bergantino, E. | 登録日 | 2015-02-02 | 公開日 | 2015-07-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX8. Appl.Microbiol.Biotechnol., 99, 2015
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6F6I
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![BU of 6f6i by Molmil](/molmil-images/mine/6f6i) | CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Envelope glycoprotein, ... | 著者 | Ren, J, Zhao, Y, Fry, E.E, Stuart, D.I. | 登録日 | 2017-12-05 | 公開日 | 2018-01-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection. J. Med. Chem., 61, 2018
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7Q6R
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![BU of 7q6r by Molmil](/molmil-images/mine/7q6r) | OleP mutant E89Y in complex with 6DEB | 分子名称: | 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ... | 著者 | Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E. | 登録日 | 2021-11-09 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics. Biomolecules, 12, 2021
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6F6U
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![BU of 6f6u by Molmil](/molmil-images/mine/6f6u) | Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b | 分子名称: | 2-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-1-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]ethanone, GLYCEROL, MAGNESIUM ION, ... | 著者 | Prosdocimi, T, Donini, S, Parisini, E. | 登録日 | 2017-12-06 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.828 Å) | 主引用文献 | Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds. Biochemistry, 57, 2018
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6EXK
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![BU of 6exk by Molmil](/molmil-images/mine/6exk) | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK206) - unfolded HTH motif | 分子名称: | ISOPROPYL ALCOHOL, Listeriolysin regulatory protein, SODIUM ION, ... | 著者 | Hall, M, Grundstrom, C, Begum, A, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E. | 登録日 | 2017-11-08 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J. Med. Chem., 61, 2018
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6MKH
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![BU of 6mkh by Molmil](/molmil-images/mine/6mkh) | Crystal structure of pencillin binding protein 4 (PBP4) from Enterococcus faecalis in the imipenem-bound form | 分子名称: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, PHOSPHATE ION, pencillin binding protein 4 (PBP4) | 著者 | D'Andrea, E.D, Moon, T.M, Peti, W, Page, R. | 登録日 | 2018-09-25 | 公開日 | 2018-10-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
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5II1
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![BU of 5ii1 by Molmil](/molmil-images/mine/5ii1) | Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 1-methylisochromeno[3,4-c]pyrazol-5(3H)-one | 分子名称: | 1-methyl[2]benzopyrano[3,4-c]pyrazol-5(3H)-one, Protein polybromo-1 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Myrianthopoulos, V, Mikros, E, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2016-03-01 | 公開日 | 2016-06-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. J.Med.Chem., 59, 2016
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7QOS
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6B1U
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![BU of 6b1u by Molmil](/molmil-images/mine/6b1u) | Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | 登録日 | 2017-09-19 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
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8UBG
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![BU of 8ubg by Molmil](/molmil-images/mine/8ubg) | DpHF19 filament | 分子名称: | DpHF19,Green fluorescent protein (Fragment) | 著者 | Lynch, E.M, Shen, H, Kollman, J.M, Baker, D. | 登録日 | 2023-09-22 | 公開日 | 2024-04-10 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | De novo design of pH-responsive self-assembling helical protein filaments. Nat Nanotechnol, 19, 2024
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4XX7
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3A6P
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![BU of 3a6p by Molmil](/molmil-images/mine/3a6p) | Crystal structure of Exportin-5:RanGTP:pre-miRNA complex | 分子名称: | 13-mer peptide, Exportin-5, GTP-binding nuclear protein Ran, ... | 著者 | Okada, C, Yamashita, E, Lee, S.J, Shibata, S, Katahira, J, Nakagawa, A, Yoneda, Y, Tsukihara, T. | 登録日 | 2009-09-07 | 公開日 | 2009-12-08 | 最終更新日 | 2012-04-25 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | A high-resolution structure of the pre-microRNA nuclear export machinery Science, 326, 2009
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6SP2
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![BU of 6sp2 by Molmil](/molmil-images/mine/6sp2) | CryoEM structure of SERINC from Drosophila melanogaster | 分子名称: | CARDIOLIPIN, Lauryl Maltose Neopentyl Glycol, Membrane protein TMS1d, ... | 著者 | Pye, V.E, Nans, A, Cherepanov, P. | 登録日 | 2019-08-30 | 公開日 | 2020-01-01 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | A bipartite structural organization defines the SERINC family of HIV-1 restriction factors. Nat.Struct.Mol.Biol., 27, 2020
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6F8T
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![BU of 6f8t by Molmil](/molmil-images/mine/6f8t) | Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a | 分子名称: | (2~{R})-1-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-3-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]propan-2-ol, MAGNESIUM ION, ZINC ION, ... | 著者 | Prosdocimi, T, Donini, S, Parisini, E. | 登録日 | 2017-12-13 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds. Biochemistry, 57, 2018
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6VC4
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![BU of 6vc4 by Molmil](/molmil-images/mine/6vc4) | Peanut lectin complexed with S-beta-D-Thiogalactopyranosyl beta-D-glucopyranoside derivative (STGD) | 分子名称: | (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5S,6S)-3,4,5-trihydroxy-6-({[(1-{[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl]methyl}-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}methyl)tetrahydro-2H-pyran-2-yl]sulfanyl}tetrahydro-2H-pyran-3,4,5-triol (non-preferred name), CALCIUM ION, Galactose-binding lectin, ... | 著者 | Otero, L.H, Primo, E.D, Cagnoni, A.J, Cano, M.E, Klinke, S, Goldbaum, F.A, Uhrig, M.L. | 登録日 | 2019-12-20 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of peanut lectin in the presence of synthetic beta-N- and beta-S-galactosides disclose evidence for the recognition of different glycomimetic ligands. Acta Crystallogr D Struct Biol, 76, 2020
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5EHU
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