6MKF

Crystal structure of penicillin binding protein 5 (PBP5) from Enterococcus faecium in the imipenem-bound form

Summary for 6MKF

Entry DOI	10.2210/pdb6mkf/pdb
Descriptor	penicillin binding protein 5 (PBP5), (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	transpeptidase, pbp, penicillin-binding protein, protein binding-antibiotic complex, protein binding/antibiotic
Biological source	Enterococcus faecium
Total number of polymer chains	1
Total formula weight	71601.09
Authors	Moon, T.M.,Lee, C.,D'Andrea, E.D.,Peti, W.,Page, R. (deposition date: 2018-09-25, release date: 2018-10-31, Last modification date: 2024-04-03)
Primary citation	Moon, T.M.,D'Andrea, E.D.,Lee, C.W.,Soares, A.,Jakoncic, J.,Desbonnet, C.,Garcia-Solache, M.,Rice, L.B.,Page, R.,Peti, W. The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293:18574-18584, 2018 Cited by PubMed: 30355734 DOI: 10.1074/jbc.RA118.006052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation