6F6I

CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE

Summary for 6F6I

Entry DOI	10.2210/pdb6f6i/pdb
Related	6F5U
Descriptor	Envelope glycoprotein,GP,GP1, Envelope glycoprotein, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, benztropine, bepridil, paroxetine, sertraline, toremifene, viral protein
Biological source	Ebola virus More
Total number of polymer chains	2
Total formula weight	57726.52
Authors	Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. (deposition date: 2017-12-05, release date: 2018-01-03, Last modification date: 2024-01-17)
Primary citation	Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection. J. Med. Chem., 61:724-733, 2018 Cited by PubMed: 29272110 DOI: 10.1021/acs.jmedchem.7b01249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation