6F6U

Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b

Summary for 6F6U

DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywordspde4, catalytic domain, inhibitor, gebr, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationApical cell membrane  Q08499
Total number of polymer chains2
Total molecular weight80418.76
Authors
Prosdocimi, T.,Donini, S.,Parisini, E. (deposition date: 2017-12-06, release date: 2018-05-16, Last modification date: 2018-05-23)
Primary citation
Prosdocimi, T.,Mollica, L.,Donini, S.,Semrau, M.S.,Lucarelli, A.P.,Aiolfi, E.,Cavalli, A.,Storici, P.,Alfei, S.,Brullo, C.,Bruno, O.,Parisini, E.
Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57:2876-2888, 2018
PubMed: 29652483 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.8b00288
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.828 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23170.5%1.2%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6f6u
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Molmil generated image of 6f6u
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