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6F6U

Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcAMP-specific 3',5'-cyclic phosphodiesterase 4Dpolymer34339624.92UniProt (Q08499)
Pfam (PF00233)
In PDB
Homo sapiens (Human)DPDE3,PDE43
2A, BMAGNESIUM IONnon-polymer24.33Chemie (MG)
3A, BZINC IONnon-polymer65.42Chemie (ZN)
4A, B2-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-1-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]ethanonenon-polymer390.52Chemie (CV8)
5A, BGLYCEROLnon-polymer92.12Chemie (GOL)
6waterwater18.0554Chemie (HOH)
Sequence modifications
A, B: 244 - 578 (UniProt: Q08499)
PDBExternal DatabaseDetails
Met 243-initiating methionine
Ala 579-expression tag
His 580-expression tag
His 581-expression tag
His 582-expression tag
His 583-expression tag
His 584-expression tag
His 585-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79249.9
Non-Polymers*Number of molecules9
Total formula weight1168.9
All*Total formula weight80418.8
*Water molecules are not included.

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PDB entries from 2024-03-27

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