6F6U
Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 343 | 39624.9 | 2 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | C, E, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | D, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, J (A, B) | 2-[(~{E})-(3-cyclopentyloxy-4-methoxy-phenyl)methylideneamino]oxy-1-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]ethanone | non-polymer | 390.5 | 2 | Chemie (CV8) | |||
| 5 | G, K (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 554 | Chemie (HOH) |
Sequence modifications
A, B: 244 - 578 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 243 | - | initiating methionine |
| Ala 579 | - | expression tag |
| His 580 | - | expression tag |
| His 581 | - | expression tag |
| His 582 | - | expression tag |
| His 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79249.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1168.9 | |
| All* | Total formula weight | 80418.8 |
