7DXD
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7DXF
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7DXB
| Structure of TRPC3 at 2.7 angstrom in high calcium state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Chen, L, Guo, W. | 登録日 | 2021-01-18 | 公開日 | 2022-02-02 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXC
| Structure of TRPC3 at 3.06 angstrom in low calcium state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | 著者 | Chen, L, Guo, W. | 登録日 | 2021-01-18 | 公開日 | 2022-02-02 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXG
| Structure of SAR7334-bound TRPC6 at 2.9 angstrom | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | 著者 | Chen, L, Guo, W. | 登録日 | 2021-01-18 | 公開日 | 2022-02-02 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXE
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7VVH
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7VVD
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7VUO
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7WIG
| Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | 登録日 | 2022-01-03 | 公開日 | 2022-06-01 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7WIC
| Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | 登録日 | 2022-01-03 | 公開日 | 2022-06-01 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7E16
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1DCT
| DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ... | 著者 | Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N. | 登録日 | 1995-05-17 | 公開日 | 1995-09-15 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell(Cambridge,Mass.), 82, 1995
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4U5J
| C-Src in complex with Ruxolitinib | 分子名称: | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, Proto-oncogene tyrosine-protein kinase Src | 著者 | Chen, Y, Duan, Y, Chen, L. | 登録日 | 2014-07-25 | 公開日 | 2014-09-17 | 最終更新日 | 2022-03-23 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation Plos One, 9, 2014
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8VY8
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4U2Q
| Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2 | 著者 | Duerr, K.L, Chen, L, Gouaux, E. | 登録日 | 2014-07-17 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.5247 Å) | 主引用文献 | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U2R
| Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state | 分子名称: | Glutamate receptor 2, SULFATE ION | 著者 | Duerr, K.L, Chen, L, Gouaux, E. | 登録日 | 2014-07-17 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.4114 Å) | 主引用文献 | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4WBX
| Conserved hypothetical protein PF1771 from Pyrococcus furiosus solved by sulfur SAD using Swiss Light Source data | 分子名称: | 2-keto acid:ferredoxin oxidoreductase subunit alpha | 著者 | Weinert, T, Waltersperger, S, Olieric, V, Panepucci, E, Chen, L, Rose, J.P, Wang, M, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2014-09-04 | 公開日 | 2014-12-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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4WK8
| FOXP3 forms a domain-swapped dimer to bridge DNA | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3 | 著者 | Chen, Y, Chen, L. | 登録日 | 2014-10-01 | 公開日 | 2015-01-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.4006 Å) | 主引用文献 | DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res., 43, 2015
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5X07
| Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | 著者 | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | 登録日 | 2017-01-20 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
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4YE4
| Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ... | 著者 | Kwong, P.D, Chen, L, Zhou, T. | 登録日 | 2015-02-23 | 公開日 | 2015-07-22 | 最終更新日 | 2022-03-30 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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7YSW
| Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-13 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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1G0H
| CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE-FRUCTOSE 1,6 BISPHOSPHATASE | 分子名称: | CALCIUM ION, D-MYO-INOSITOL-1-PHOSPHATE, INOSITOL MONOPHOSPHATASE | 著者 | Johnson, K.A, Chen, L, Yang, H, Roberts, M.F, Stec, B. | 登録日 | 2000-10-06 | 公開日 | 2001-03-14 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities. Biochemistry, 40, 2001
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1G0I
| CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE-FRUCTOSE 1,6 BISPHOSPHATASE | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, INOSITOL MONOPHOSPHATASE, MANGANESE (II) ION, ... | 著者 | Johnson, K.A, Chen, L, Yang, H, Roberts, M.F, Stec, B. | 登録日 | 2000-10-06 | 公開日 | 2001-03-14 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities. Biochemistry, 40, 2001
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5JKG
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