7DXE

Structure of TRPC3 gain of function mutation R803C at 3.2 angstrom in 1340nM free calcium state

Summary for 7DXE

Entry DOI	10.2210/pdb7dxe/pdb
EMDB information	30906 7620
Descriptor	Short transient receptor potential channel 3, CHOLESTEROL HEMISUCCINATE, ZINC ION, ... (5 entities in total)
Functional Keywords	trpc3, trpc, calcium, gain of function, channel, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	394152.60
Authors	Chen, L.,Guo, W. (deposition date: 2021-01-18, release date: 2022-02-02, Last modification date: 2024-06-05)
Primary citation	Guo, W.,Tang, Q.,Wei, M.,Kang, Y.,Wu, J.X.,Chen, L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110:1023-1035.e5, 2022 Cited by PubMed: 35051376 DOI: 10.1016/j.neuron.2021.12.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation