5X07

Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site

Summary for 5X07

• Entry DOI: 10.2210/pdb5x07/pdb
• Descriptor: DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Hepatocyte nuclear factor 3-beta (3 entities in total)
• Functional Keywords: foxa2, forkhead domain, consensus binding site, isothermal titration calorimetry, itc, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9Y261
• Total number of polymer chains: 12
• Total formula weight: 88738.59

Authors

Li, J.,Guo, M.,Zhou, Z.,Jiang, L.,Chen, X.,Qu, L.,Wu, D.,Chen, Z.,Chen, L.,Chen, Y. (deposition date: 2017-01-20, release date: 2017-08-16, Last modification date: 2017-09-27)

• Primary citation: Li, J.,Machado, A.C.D.,Guo, M.,Sagendorf, J.M.,Zhou, Z.,Jiang, L.,Chen, X.,Wu, D.,Qu, L.,Chen, Z.,Chen, L.,Rohs, R.,Chen, Y.; Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site; Biochemistry, 56:3745-3753, 2017; PubMed: 28644006; DOI: 10.1021/acs.biochem.7b00211

Experimental method

X-RAY DIFFRACTION (2.796 Å)