Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site

Summary for 5X07

DescriptorDNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Hepatocyte nuclear factor 3-beta (3 entities in total)
Functional Keywordsfoxa2, forkhead domain, consensus binding site, isothermal titration calorimetry, itc, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q9Y261
Total number of polymer chains12
Total molecular weight88738.59
Li, J.,Guo, M.,Zhou, Z.,Jiang, L.,Chen, X.,Qu, L.,Wu, D.,Chen, Z.,Chen, L.,Chen, Y. (deposition date: 2017-01-20, release date: 2017-08-16, Last modification date: 2017-09-27)
Primary citation
Li, J.,Machado, A.C.D.,Guo, M.,Sagendorf, J.M.,Zhou, Z.,Jiang, L.,Chen, X.,Wu, D.,Qu, L.,Chen, Z.,Chen, L.,Rohs, R.,Chen, Y.
Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56:3745-3753, 2017
PubMed: 28644006 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.7b00211
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.279195.2%6.3%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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