7DXF

Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state

Summary for 7DXF

Entry DOI	10.2210/pdb7dxf/pdb
EMDB information	30907 6856
Descriptor	Short transient receptor potential channel 6, ZINC ION, [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3R,5S)-3,5-dimethylpiperidin-1-yl]methanone, ... (7 entities in total)
Functional Keywords	trpc6, trpc, calcium, btdm, fsgs, channel, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	439358.27
Authors	Chen, L.,Guo, W. (deposition date: 2021-01-18, release date: 2022-02-02, Last modification date: 2024-06-05)
Primary citation	Guo, W.,Tang, Q.,Wei, M.,Kang, Y.,Wu, J.X.,Chen, L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110:1023-1035.e5, 2022 Cited by PubMed: 35051376 DOI: 10.1016/j.neuron.2021.12.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation