4WK8

FOXP3 forms a domain-swapped dimer to bridge DNA

Summary for 4WK8

DescriptorDNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), Forkhead box protein P3 (3 entities in total)
Functional Keywordsfoxp3, regulatory t cells, dna bridging, transcription regulation, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  Q9BZS1
Total number of polymer chains4
Total molecular weight33045.87
Authors
Chen, Y.,Chen, L. (deposition date: 2014-10-01, release date: 2015-01-21, Last modification date: 2017-09-27)
Primary citation
Chen, Y.,Chen, C.,Zhang, Z.,Liu, C.C.,Johnson, M.E.,Espinoza, C.A.,Edsall, L.E.,Ren, B.,Zhou, X.J.,Grant, S.F.,Wells, A.D.,Chen, L.
DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43:1268-1282, 2015
PubMed: 25567984 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gku1373
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.4006 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253247.1%13.2%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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