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PDB: 25 件
7D6Y
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eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Eukaryotic translation initiation factor 4E, VH Domain (1C5), ...
著者Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
登録日2020-10-02
公開日2021-10-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.668 Å)
主引用文献Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
To Be Published
7XTP
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BU of 7xtp by Molmil
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
分子名称: Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
著者Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
登録日2022-05-17
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.828 Å)
主引用文献Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
5XXK
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Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
分子名称: E3 ubiquitin-protein ligase Mdm2, Hydrocarbon stapled peptide THC-SER-PHE-0EH-GLU-TYR-6CW-ALA-LEU-LEU-MK8-NH2
著者Brown, C.J.
登録日2017-07-04
公開日2017-12-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.
PLoS ONE, 12, 2017
6AAW
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Mdm2 in complex with a D amino Acid Containing Stapled Peptide
分子名称: ACE-LEU-THR-PHE-STQ-GLU-TYR-DTR-GLN-LEU-CBA-MK8-SER-ALA-ALA, E3 ubiquitin-protein ligase Mdm2
著者Brown, C.J, Partridge, A.W.
登録日2018-07-19
公開日2019-07-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Model System to Explore Macrocyclic Peptide Structural and Chirality Relationships: Tolerance of helix-breaking residues within the context of a stapled peptide.
To Be Published
2V8W
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BU of 2v8w by Molmil
Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
著者Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
登録日2007-08-16
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2V8X
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Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
分子名称: 7-BENZYL GUANINE MONOPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
著者Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
登録日2007-08-16
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2W97
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Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide
分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GLYCEROL, ...
著者Brown, C.J, Verma, C.S, Walkinshaw, M.D, Lane, D.P.
登録日2009-01-22
公開日2010-03-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.
Cell Cycle, 8, 2009
2V8Y
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BU of 2v8y by Molmil
Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives
分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, P-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE
著者Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D.
登録日2007-08-16
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
5GW6
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BU of 5gw6 by Molmil
Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
分子名称: Eukaryotic translation initiation factor 4E, GLYCEROL
著者Brown, C.J.
登録日2016-09-08
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Structure, 25, 2017
7EZW
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BU of 7ezw by Molmil
Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site
分子名称: ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, Eukaryotic translation initiation factor 4E, SODIUM ION
著者Brown, C.J, Ng, S, Frosi, Y.
登録日2021-06-02
公開日2022-06-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
Rsc Chem Biol, 3, 2022
7F07
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BU of 7f07 by Molmil
Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site.
分子名称: Eukaryotic translation initiation factor 4E, VH domain (VH-DiFCAP-01)
著者Brown, C.J, Frosi, Y, Ng, S, Lin, Y.C.
登録日2021-06-03
公開日2022-06-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
Rsc Chem Biol, 3, 2022
7D8B
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BU of 7d8b by Molmil
Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
分子名称: Eukaryotic translation initiation factor 4E, VH-S4
著者Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J.
登録日2020-10-07
公開日2021-08-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
6KZU
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BU of 6kzu by Molmil
Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled alpha-helical peptide modality
分子名称: 2JN-DAL-E03-DTY-2JN-DSG-TDF-DGL-MK8-DLE-DLE-2JN, E3 ubiquitin-protein ligase Mdm2
著者Jiang, S, Brown, C.J.
登録日2019-09-25
公開日2019-10-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Macrocyclization of an all-d linear alpha-helical peptide imparts cellular permeability.
Chem Sci, 11, 2020
4UMN
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BU of 4umn by Molmil
Structure of a stapled peptide antagonist bound to Nutlin-resistant Mdm2.
分子名称: E3 ubiquitin-protein ligase Mdm2, M06
著者Chee, S, Wongsantichon, J, Quah, S, Robinson, R.C, Verma, C, Lane, D.P, Brown, C.J, Ghadessy, F.J.
登録日2014-05-20
公開日2014-05-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.
PLoS ONE, 9, 2014
4UD7
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Structure of the stapled peptide YS-02 bound to MDM2
分子名称: MDM2, YS-02
著者Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C.
登録日2014-12-08
公開日2016-01-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
4UE1
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BU of 4ue1 by Molmil
Structure of the stapled peptide YS-01 bound to MDM2
分子名称: E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01
著者Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C.
登録日2014-12-14
公開日2016-01-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
8GU0
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BU of 8gu0 by Molmil
Crystal structure of a fungal halogenase RadH
分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Non-heme halogenase radH, ...
著者Jiang, S.M, Brown, C.J.
登録日2022-09-09
公開日2023-07-26
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Further Characterization of Fungal Halogenase RadH and Its Homologs.
Biomolecules, 13, 2023
5ZK9
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BU of 5zk9 by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-ILE-ILE-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-LYS-NH2, DI(HYDROXYETHYL)ETHER, ...
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
登録日2018-03-23
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK7
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BU of 5zk7 by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2, CHLORIDE ION, ...
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
登録日2018-03-23
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZML
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BU of 5zml by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 1,2-ETHANEDIOL, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, Eukaryotic translation initiation factor 4E, ...
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Yano, J.
登録日2018-04-04
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZJY
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BU of 5zjy by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-LYS-ARG-TYR-SER-ARG-2JN-GLN-LEU-LEU-2JN-PHE
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, B, Uhring, M.
登録日2018-03-22
公開日2019-03-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK5
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BU of 5zk5 by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
登録日2018-03-23
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZJZ
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BU of 5zjz by Molmil
Stapled-peptides tailored against initiation of translation
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E
著者Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M.
登録日2018-03-22
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
4BEA
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BU of 4bea by Molmil
Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative
分子名称: Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE
著者Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J.
登録日2013-03-07
公開日2013-12-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces.
Sci.Rep., 3, 2013
4AZA
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Improved eIF4E binding peptides by phage display guided design.
分子名称: EIF4G1_D5S PEPTIDE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
著者Chew, W.Z, Quah, S.T, Verma, C.S, Liu, Y, Lane, D.P, Brown, C.J.
登録日2012-06-25
公開日2012-08-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects.
Plos One, 7, 2012

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