7XTP

eIF4E in Complex with a Disulphide-Free Autonomous VH Domain

Summary for 7XTP

• Entry DOI: 10.2210/pdb7xtp/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE, ... (4 entities in total)
• Functional Keywords: cap-dependent translation, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 84343.51

Authors

Brown, C.J.,Frosi, Y.,Jiang, S.,Lin, Y.C. (deposition date: 2022-05-17, release date: 2022-07-27, Last modification date: 2023-11-29)

• Primary citation: Frosi, Y.,Lin, Y.C.,Shimin, J.,Ramlan, S.R.,Hew, K.,Engman, A.H.,Pillai, A.,Yeung, K.,Cheng, Y.X.,Cornvik, T.,Nordlund, P.,Goh, M.,Lama, D.,Gates, Z.P.,Verma, C.S.,Thean, D.,Lane, D.P.,Asial, I.,Brown, C.J.; Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.; Nat Commun, 13:4854-4854, 2022; PubMed: 35982046; DOI: 10.1038/s41467-022-32463-1

Experimental method

X-RAY DIFFRACTION (1.828 Å)