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6AAW

Mdm2 in complex with a D amino Acid Containing Stapled Peptide

Summary for 6AAW
Entry DOI10.2210/pdb6aaw/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, ACE-LEU-THR-PHE-STQ-GLU-TYR-DTR-GLN-LEU-CBA-MK8-SER-ALA-ALA (3 entities in total)
Functional Keywordse3 ligase, ligase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight15523.82
Authors
Brown, C.J.,Partridge, A.W. (deposition date: 2018-07-19, release date: 2019-07-24, Last modification date: 2023-11-29)
Primary citationPartridge, A.W.,Hung, Y.K.K.,Juang, Y.,Sadruddin, A.,Lim, S.,Brown, C.J.,Ng, S.,Thean, D.,Ferrer, F.,Johannes, C.,Yuen, T.Y.,Kannan, S.,Aronica, P.,Tan, Y.S.,Mohan, P.R.,Verma, C.S.,Hichman, J.,Chen, S.,Wan, H.,Lane, D.P.,Sawyer, T.K.
A Model System to Explore Macrocyclic Peptide Structural and Chirality Relationships: Tolerance of helix-breaking residues within the context of a stapled peptide.
To Be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

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