7EZW

Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site

Summary for 7EZW

Entry DOI	10.2210/pdb7ezw/pdb
Descriptor	Eukaryotic translation initiation factor 4E, ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, SODIUM ION, ... (4 entities in total)
Functional Keywords	ap dependent translation, rna binding protein-inhibitor complex, rna binding protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	26358.60
Authors	Brown, C.J.,Ng, S.,Frosi, Y. (deposition date: 2021-06-02, release date: 2022-06-08, Last modification date: 2023-11-29)
Primary citation	Frosi, Y.,Ng, S.,Lin, Y.C.,Jiang, S.,Ramlan, S.R.,Lama, D.,Verma, C.S.,Asial, I.,Brown, C.J. Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE). Rsc Chem Biol, 3:916-930, 2022 Cited by PubMed: 35866173 DOI: 10.1039/d2cb00099g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation