2W97

Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide

Summary for 2W97

Entry DOI	10.2210/pdb2w97/pdb
Related	1IPB 1IPC 1LJ2 1UG3 2V8W 2V8X 2V8Y
Descriptor	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE, ... (8 entities in total)
Functional Keywords	protein biosynthesis, initiation factor, translation regulation, translation
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	55233.71
Authors	Brown, C.J.,Verma, C.S.,Walkinshaw, M.D.,Lane, D.P. (deposition date: 2009-01-22, release date: 2010-03-31, Last modification date: 2023-12-13)
Primary citation	Brown, C.J.,Verma, C.S.,Walkinshaw, M.D.,Lane, D.P. Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site. Cell Cycle, 8:1905-1911, 2009 Cited by PubMed: 19440045 DOI: 10.4161/cc.8.12.8742 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation