2W97
Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | polymer | 217 | 25130.2 | 1 | UniProt (P06730) Pfam (PF01652) | HOMO SAPIENS (HUMAN) | MRNA CAP-BINDING PROTEIN, EIF-4F 25 KDA SUBUNIT, EIF-4E, EIF4E |
| 2 | B (B) | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E | polymer | 217 | 25145.3 | 1 | UniProt (P06730) Pfam (PF01652) | HOMO SAPIENS (HUMAN) | MRNA CAP-BINDING PROTEIN, EIF-4F 25 KDA SUBUNIT, EIF-4E, EIF4E |
| 3 | C, D (E, F) | EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1 | polymer | 14 | 1851.2 | 2 | UniProt (Q04637) | HOMO SAPIENS | P220, EIF-4-GAMMA 1, EIF-4G 1, EIF-4G1, EIF4GI |
| 4 | E (A) | [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | non-polymer | 537.2 | 1 | Chemie (MGO) | |||
| 5 | F (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 6 | G, H, J, K (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | I, L (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | M, N, O, P (A, B, E, F) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
B: 1 - 217 (UniProt: P06730)
| PDB | External Database | Details |
|---|---|---|
| Lys 50 | Asn 50 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 53977.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1255.8 | |
| All* | Total formula weight | 55233.7 |
