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2W97

Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000932cellular_componentP-body
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006417biological_processregulation of translation
A0010494cellular_componentcytoplasmic stress granule
A0010507biological_processnegative regulation of autophagy
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016442cellular_componentRISC complex
A0016604cellular_componentnuclear body
A0016607cellular_componentnuclear speck
A0017148biological_processnegative regulation of translation
A0019899molecular_functionenzyme binding
A0031370molecular_functioneukaryotic initiation factor 4G binding
A0033391cellular_componentchromatoid body
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045931biological_processpositive regulation of mitotic cell cycle
A0048471cellular_componentperinuclear region of cytoplasm
A0051028biological_processmRNA transport
A0051168biological_processnuclear export
A0060076cellular_componentexcitatory synapse
A0070062cellular_componentextracellular exosome
A0098794cellular_componentpostsynapse
A0098808molecular_functionmRNA cap binding
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A0140297molecular_functionDNA-binding transcription factor binding
B0000082biological_processG1/S transition of mitotic cell cycle
B0000339molecular_functionRNA cap binding
B0000340molecular_functionRNA 7-methylguanosine cap binding
B0000932cellular_componentP-body
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006406biological_processmRNA export from nucleus
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0006417biological_processregulation of translation
B0010494cellular_componentcytoplasmic stress granule
B0010507biological_processnegative regulation of autophagy
B0016281cellular_componenteukaryotic translation initiation factor 4F complex
B0016442cellular_componentRISC complex
B0016604cellular_componentnuclear body
B0016607cellular_componentnuclear speck
B0017148biological_processnegative regulation of translation
B0019899molecular_functionenzyme binding
B0031370molecular_functioneukaryotic initiation factor 4G binding
B0033391cellular_componentchromatoid body
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0045931biological_processpositive regulation of mitotic cell cycle
B0048471cellular_componentperinuclear region of cytoplasm
B0051028biological_processmRNA transport
B0051168biological_processnuclear export
B0060076cellular_componentexcitatory synapse
B0070062cellular_componentextracellular exosome
B0098794cellular_componentpostsynapse
B0098808molecular_functionmRNA cap binding
B0098978cellular_componentglutamatergic synapse
B0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
B0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE MGO A 1218
ChainResidue
ATRP56
AHOH2040
AHOH2076
AHOH2077
AHOH2078
AHOH2079
AHOH2080
AHOH2081
BGLU103
AMET101
ATRP102
AGLU103
AARG157
ALYS162
ASER207
AGLY208
AHOH2022

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PGE A 1219
ChainResidue
AASP96
AGLY97
AASN118
ALYS119
AGLN120
AASP147
AVAL149
AHOH2082

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1220
ChainResidue
AARG42
ALYS65
ALYS119

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1221
ChainResidue
AGLU171
AARG173
AGLU174

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1218
ChainResidue
BARG42
BLYS65
BLYS119

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1219
ChainResidue
BGLU171
BARG173
BGLU174
BHOH2061

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 1220
ChainResidue
BARG112
BHIS200
BTHR203

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 1222
ChainResidue
ATHR116
AGLN121
AILE195

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
BASP90-TRP113
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsRegion: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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