7F07
Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site.
Summary for 7F07
| Entry DOI | 10.2210/pdb7f07/pdb |
| Descriptor | Eukaryotic translation initiation factor 4E, VH domain (VH-DiFCAP-01) (3 entities in total) |
| Functional Keywords | inhibitor complex, cap-dependent translation, vh domain, rna binding protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 44240.74 |
| Authors | Brown, C.J.,Frosi, Y.,Ng, S.,Lin, Y.C. (deposition date: 2021-06-03, release date: 2022-06-08, Last modification date: 2023-11-29) |
| Primary citation | Frosi, Y.,Ng, S.,Lin, Y.C.,Jiang, S.,Ramlan, S.R.,Lama, D.,Verma, C.S.,Asial, I.,Brown, C.J. Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE). Rsc Chem Biol, 3:916-930, 2022 Cited by PubMed: 35866173DOI: 10.1039/d2cb00099g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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